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| Synonym: | NEM |
| CAS Number: | 128-53-0 |
| Linear Formula: | C6H7NO2 |
| Molecular Weight: | 125.13 |
| Beilstein Registry Number: | 112448 |
| EC Number: | 204-892-4 |
| MDL number: | MFCD00005509 |
| PubChem Substance ID: | 24847840 |
Description
| Application | Thiol reagent.1,2 |
| | Reagent for the covalent modification of cysteine residues in proteins. |
| Biochem/physiol Actions | Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. |
| | Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases. |
Properties
| assay | 98% |
| bp | 210 °C(lit.) |
| mp | 43-46 °C(lit.) |
| Gene Information | human ... SLC6A3(6531), SLC6A4(6532) |
Safety
References
| Cited Reference | 1. Anal. Biochem. 217, 323, (1994) Abstract |
| | 2. Aldrichimica Acta 4, 33, (1971) |
| reference | Riordan, J.F. and Vallee, B.L., Reagent for the modification of sulfhydryl groups in proteins. Meth. Enzymol. 25, 449-456, (1972) |
| | W.J.H. Van Berkel et al. Eur. J. Biochem. 145, 245, (1984) |
| Merck | Merck 13,3855 |
| Beilstein | Beil. 21,V,10,6 |
| | Aldrich MSDS 1, 918:D / Corp MSDS 1 (1), 1631:C / FT-IR 1 (1), 797:D / FT-IR 2 (1), 1354:B / FT-NMR 1 (1), 1304:A / IR-Spectra (2), 419:G / IR-Spectra (3), 473:C / NMR-Reference 2 (1), 669:A / RegBook 1 (1), 935:B / Sax 6, 1726 / Sigma FT-IR 1 (2), 555:D / Structure Index 1, 145:B:6 |
